human IDH2 shRNA silencing Adenovirus

Name 
Ad-h-IDH2-shRNA
Cat No 
shADV-211771
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human IDH2.

shADV-211771
Ad-h-IDH2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human IDH2 (isocitrate dehydrogenase (NADP(+)) 2, mitochondrial). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; isocitrate dehydrogenase NADP, mitochondrial; isocitrate dehydrogenase 2 (NADP+), mitochondrial; mNADP-IDH; NADP(+)-specific ICDH; oxalosuccinate decarboxylase
Description (eCommerce)
Isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2) plays a role in intermediary metabolism and energy production. IDH2 may tightly associate or interact with the pyruvate dehydrogenase complex [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P48735].
Description (Vector)
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.
Gene ID
3418
Gene Name (eCommerce)
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
Gene Name (Vector)
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
Gene Symbol
IDH2
HGNC ID
HGNC:5383
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1359
ORF Size (bp)
1359 bp
Protein Name (eCommerce)
Isocitrate dehydrogenase [NADP], mitochondrial
RefSeq ID
NM_002168
RefSeq Synonyms
NM_002168, NM_001290114, NM_001289910, BC071828, BC009244,
Research Areas
Metabolism/Metabolic Process,Mitochondrion
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
Isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2) plays a role in intermediary metabolism and energy production. IDH2 may tightly associate or interact with the pyruvate dehydrogenase complex [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P48735].
UniGene ID
Hs.596461
UniProt ID (eCommerce)
P48735

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.