human ICOS shRNA silencing Adenovirus

Name 
Ad-h-ICOS-shRNA
Cat No 
shADV-211758
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ICOS.

shADV-211758
Ad-h-ICOS-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ICOS (inducible T-cell costimulator). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
activation-inducible lymphocyte immunomediatory molecule; AILIM; CD antigen CD278; CD278; CVID1; inducible costimulator; inducible T-cell costimulator; inducible T-cell co-stimulator
Description (eCommerce)
ICOS is a member of the CD28 and CTLA-4 cell-surface receptor family. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. ICOS is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y6W8].
Description (Vector)
ICOS belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
Gene ID
29851
Gene Name (eCommerce)
inducible T cell costimulator
Gene Name (Vector)
inducible T-cell costimulator
Gene Symbol
ICOS
HGNC ID
HGNC:5351
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
600
Protein Name (eCommerce)
Inducible T-cell costimulator
RefSeq ID
NM_012092
RefSeq Synonyms
NM_012092, BC028210, BC028006,
Research Areas
Immunology,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
signal_transduction,immunology
Species
human
Target Sentence
ICOS is a member of the CD28 and CTLA-4 cell-surface receptor family. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. ICOS is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y6W8].
UniGene ID
Hs.56247
UniProt ID (eCommerce)
Q9Y6W8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.