human HSD11B1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human HSD11B1.
shADV-211557
Ad-h-HSD11B1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
11-beta-HSD1; 11-DH; CORTRD2; HDL; HSD11; HSD11B; HSD11L; SDR26C1
Description (Vector)
HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.
Gene ID
3290
Gene Name (Vector)
hydroxysteroid 11-beta dehydrogenase 1
Gene Symbol
HSD11B1
HGNC ID
HGNC:5208
ORF Size (aa)
879
ORF Size (bp)
879 bp
RefSeq ID
NM_181755
RefSeq Synonyms
NM_181755, NM_005525, NM_001206741, BC012593,
Species
human
UniGene ID
Hs.195040
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.