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human HMMR shRNA silencing Adenovirus

Name 
Ad-h-HMMR-shRNA
Cat No 
shADV-211313
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human HMMR.

shADV-211313
Ad-h-HMMR-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human HMMR (hyaluronan mediated motility receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD antigen CD168; CD168; hyaluronan mediated motility receptor; IHABP; intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motility; RHAMM
Description (eCommerce)
CD168 / RHAMM (Receptor for hyaluronan-mediated motility) is involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. it may also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75330].
Description (Vector)
HMMR is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Gene ID
3161
Gene Name (eCommerce)
hyaluronan mediated motility receptor
Gene Name (Vector)
hyaluronan mediated motility receptor
Gene Symbol
HMMR
HGNC ID
HGNC:5012
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2178
ORF Size (bp)
2178 bp
Protein Name (eCommerce)
Hyaluronan mediated motility receptor
RefSeq ID
NM_012484
RefSeq Synonyms
NM_012485, NM_012484, NM_001142557, NM_001142556, BC108905, BC108904,
Research Areas
Metabolism/Metabolic Process
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
CD168 / RHAMM (Receptor for hyaluronan-mediated motility) is involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. it may also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75330].
UniGene ID
Hs.72550
UniProt ID (eCommerce)
O75330

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.