human HDAC7 shRNA silencing Adenovirus

Name 
Ad-h-HDAC7-shRNA
Cat No 
shADV-210893
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human HDAC7.

shADV-210893
Ad-h-HDAC7-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human HDAC7 (histone deacetylase 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
HD7; HD7A; HDAC7A; histone deacetylase 7; histone deacetylase 7A
Description (eCommerce)
Histone deacetylase 7 (HDAC7) is a class II histone deacetylase that catalyzes the removal of acetyl groups from core histone octamer subunits. HDAC7 appears to have an influence on cellular processes by acting as a transcriptional repressor. HDAC7 is highly expressed in double positive thymocytes and may play an important role in T-cell development. Recently, HDAC7 has also been reported to influence endothelial cell migration and modulate angiogenesis.
Description (Vector)
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
51564
Gene Name (eCommerce)
histone deacetylase 7
Gene Name (Vector)
histone deacetylase 7
Gene Symbol
HDAC7
HGNC ID
HGNC:14067
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2865
ORF Size (bp)
2865 bp
Protein Name (eCommerce)
Histone deacetylase 7
RefSeq ID
NM_015401
RefSeq Synonyms
NM_015401, NM_001308090, NM_001098416, BC064840, BC006453,
Research Areas
Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cell Cycle,Chromatin Remodeling,Histone Modification,Host-Virus Interactions,Immunology,Neurobiology,Neurodevelopment,Notch Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,Transcription Factor/Regulator,Viral Carcinogenesis
Research Areas (Faceted)
cancer,signal_transduction,cardiovascular,cell_biology,cell_cycle,transcription_translation,genetics,infectious_disease,immunology,neurobiology,developmental_biology,developmental_biology,signal_transduction,immunology,genetics,transcription_translation,cancer,infectious_disease
Species
human
Target Sentence
Histone deacetylase 7 (HDAC7) is a class II histone deacetylase that catalyzes the removal of acetyl groups from core histone octamer subunits. HDAC7 appears to have an influence on cellular processes by acting as a transcriptional repressor. HDAC7 is highly expressed in double positive thymocytes and may play an important role in T-cell development. Recently, HDAC7 has also been reported to influence endothelial cell migration and modulate angiogenesis.
UniGene ID
Hs.200063
UniProt ID (eCommerce)
Q8WUI4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.