human HDAC3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human HDAC3.
shADV-210888
Ad-h-HDAC3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human HDAC3 (histone deacetylase 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HD3; histone deacetylase 3; RPD3; RPD3-2; SMAP45
Description (eCommerce)
Histone deacetylase 3 (HDAC3) is a class I histone deacetylase that catalyzes the removal of the acetyl group on lysine residues of the N-terminus of the core histones H2A, H2B, H3, and H4. HDAC3 is found in multi-protein complexes and its activity depends on its interaction with the co-repressors SMRT and N-CoR.
Description (Vector)
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Gene ID
8841
Gene Name (eCommerce)
histone deacetylase 3
Gene Name (Vector)
histone deacetylase 3
Gene Symbol
HDAC3
HGNC ID
HGNC:4854
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1287
ORF Size (bp)
1287 bp
Protein Name (eCommerce)
Histone deacetylase 3
RefSeq ID
NM_003883
RefSeq Synonyms
NM_003883, BC000614,
Research Areas
Apoptosis,Cancer,Cell Cycle,Chromatin Remodeling,Histone Modification,Host-Virus Interactions,JNK Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,NGF Signaling,Notch Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Viral Carcinogenesis
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cell_cycle,transcription_translation,genetics,infectious_disease,signal_transduction,metabolism,neurobiology,developmental_biology,developmental_biology,signal_transduction,immunology,genetics,transcription_translation,cancer,infectious_disease
Species
human
Target Sentence
Histone deacetylase 3 (HDAC3) is a class I histone deacetylase that catalyzes the removal of the acetyl group on lysine residues of the N-terminus of the core histones H2A, H2B, H3, and H4. HDAC3 is found in multi-protein complexes and its activity depends on its interaction with the co-repressors SMRT and N-CoR.
UniGene ID
Hs.519632
UniProt ID (eCommerce)
O15379
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.