human HDAC1 shRNA silencing Adenovirus

Name 
Ad-h-HDAC1-shRNA
Cat No 
shADV-210883
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human HDAC1.

shADV-210883
Ad-h-HDAC1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human HDAC1 (histone deacetylase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
GON-10; HD1; histone deacetylase 1; reduced potassium dependency, yeast homolog-like 1; RPD3; RPD3L1
Description (eCommerce)
Histone deacetylase 1 (HDAC1) is a class I histone deacetylase that catalyzes the removal of the acetyl group on lysine residues of the N-terminus of the core histones H2A, H2B, H3, and H4. HDAC1 is a component of multiple deacetylating complexes such as Sin3, NuRD, and CoRest that function to repress gene transcription.
Description (Vector)
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Gene ID
3065
Gene Name (eCommerce)
histone deacetylase 1
Gene Name (Vector)
histone deacetylase 1
Gene Symbol
HDAC1
HGNC ID
HGNC:4852
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1449
ORF Size (bp)
1449 bp
Protein Name (eCommerce)
Histone deacetylase 1
RefSeq ID
NM_004964
RefSeq Synonyms
NM_004964, BC000301,
Research Areas
Apoptosis,Breast Cancer,Cancer,Cell Cycle,Chromatin Remodeling,EGFR Signaling,Epigenetic Regulation of Gene Expression,Gene Expression,Hedgehog Signaling,Histone Modification,Host-Virus Interactions,Huntington's Disease,Immunology,Interleukin Signaling,Leukemia,Metabolism/Metabolic Process,MicroRNAs in Cancer,Neurobiology,Neurodegeneration,Neurodevelopment,NGF Signaling,Notch Signaling,Signal Transduction,TGF-beta Signaling,TNF Signaling,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,TWEAK Signaling,Viral Carcinogenesis,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
Histone deacetylase 1 (HDAC1) is a class I histone deacetylase that catalyzes the removal of the acetyl group on lysine residues of the N-terminus of the core histones H2A, H2B, H3, and H4. HDAC1 is a component of multiple deacetylating complexes such as Sin3, NuRD, and CoRest that function to repress gene transcription.
UniGene ID
Hs.88556
UniProt ID (eCommerce)
Q13547

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.