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human HAT1 shRNA silencing Adenovirus

Name 
Ad-h-HAT1-shRNA
Cat No 
shADV-210794
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human HAT1.

shADV-210794
Ad-h-HAT1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human HAT1 (histone acetyltransferase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Histone acetyltransferase 1; histone acetyltransferase type B catalytic subunit; KAT1
Description (eCommerce)
Histone acetyltransferase 1 (HAT1) is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5 [taken from NCBI Entrez Gene (Gene ID: 8520)].
Description (Vector)
HAT1 is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene.
Gene ID
8520
Gene Name (eCommerce)
histone acetyltransferase 1
Gene Name (Vector)
histone acetyltransferase 1
Gene Symbol
HAT1
HGNC ID
HGNC:4821
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1005
ORF Size (bp)
1005 bp
Protein Name (eCommerce)
Histone acetyltransferase type B catalytic subunit
RefSeq ID
NM_003642
RefSeq Synonyms
NM_003642, BC063003,
Research Areas
Acyltransferase,EGFR Signaling,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
Histone acetyltransferase 1 (HAT1) is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5 [taken from NCBI Entrez Gene (Gene ID: 8520)].
UniGene ID
Hs.632532
UniProt ID (eCommerce)
O14929

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.