human HAS2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human HAS2.
shADV-210790
Ad-h-HAS2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human HAS2 (hyaluronan synthase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
Gene ID
3037
Gene Name (Vector)
hyaluronan synthase 2
Gene Symbol
HAS2
HGNC ID
HGNC:4819
ORF Size (aa)
1659
ORF Size (bp)
1659 bp
RefSeq ID
NM_005328
RefSeq Synonyms
NM_005328, BC109072, BC109071, BC069353,
Species
human
UniGene ID
Hs.159226
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.