human HAMP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human HAMP.
shADV-210772
Ad-h-HAMP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human HAMP (hepcidin antimicrobial peptide). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HEPC; HFE2B; LEAP1; PLTR
Description (Vector)
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
Gene ID
57817
Gene Name (Vector)
hepcidin antimicrobial peptide
Gene Symbol
HAMP
HGNC ID
HGNC:15598
ORF Size (aa)
255
RefSeq ID
NM_021175
RefSeq Synonyms
NM_021175, BC020612,
Species
human
UniGene ID
Hs.8821
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.