human GTF2B shRNA silencing Adenovirus

Name 
Ad-h-GTF2B-shRNA
Cat No 
shADV-210632
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human GTF2B.

shADV-210632
Ad-h-GTF2B-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GTF2B (general transcription factor IIB). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
general transcription factor TFIIB; RNA polymerase II transcription factor IIB; S300-II; TF2B; TFIIB; transcription initiation factor IIB
Description (eCommerce)
GTF2B/TFIIB (General transcription factor IIB) is one of the ubiquitous factors required for transcription initiation by RNA polymerase II. GTF2B/TFIIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II [taken from NCBI Entrez Gene (Gene ID: 2959)].
Description (Vector)
GTF2B encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II.
Gene ID
2959
Gene Name (eCommerce)
general transcription factor IIB
Gene Name (Vector)
general transcription factor IIB
Gene Symbol
GTF2B
HGNC ID
HGNC:4648
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
951
ORF Size (bp)
951 bp
Protein Name (eCommerce)
Transcription initiation factor IIB
RefSeq ID
NM_001514
RefSeq Synonyms
NM_001514, BC020597,
Research Areas
Cancer,Chromatin Remodeling,Gene Expression,Host-Virus Interactions,Transcription Factor/Regulator,Viral Carcinogenesis,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation,infectious_disease
Species
human
Target Sentence
GTF2B/TFIIB (General transcription factor IIB) is one of the ubiquitous factors required for transcription initiation by RNA polymerase II. GTF2B/TFIIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II [taken from NCBI Entrez Gene (Gene ID: 2959)].
UniGene ID
Hs.481852
UniProt ID (eCommerce)
Q00403

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.