human GPX1 shRNA silencing Adenovirus

Name 
Ad-h-GPX1-shRNA
Cat No 
shADV-210454
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human GPX1.

shADV-210454
Ad-h-GPX1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GPX1 (glutathione peroxidase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
GPXD; GSHPX1
Description (Vector)
GPX1 encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Gene ID
2876
Gene Name (Vector)
glutathione peroxidase 1
Gene Symbol
GPX1
HGNC ID
HGNC:4553
ORF Size (aa)
438
RefSeq ID
NM_000581
RefSeq Synonyms
NM_201397, NM_001329503, NM_001329502, NM_001329455, NM_000581, BC070258, BC007865, BC000742,
Species
human
UniGene ID
Hs.76686

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.