human GOLPH3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human GOLPH3.
shADV-210166
Ad-h-GOLPH3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human GOLPH3 (golgi phosphoprotein 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
coat protein GPP34; coat-protein; golgi peripheral membrane protein 1, 34 kDa; Golgi phosphoprotein 3; golgi protein; golgi-associated protein; GOPP1; GPP34; MIDAS; mitochondrial DNA absence factor; Vps74
Description (eCommerce)
GOLPH3 is a phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H4A6].
Description (Vector)
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined.
Gene ID
64083
Gene Name (eCommerce)
golgi phosphoprotein 3
Gene Name (Vector)
golgi phosphoprotein 3
Gene Symbol
GOLPH3
HGNC ID
HGNC:15452
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
897
Protein Name (eCommerce)
Golgi phosphoprotein 3
RefSeq ID
NM_022130
RefSeq Synonyms
NM_022130, BC063586, BC033725, BC012123,
Research Areas
Cancer,Golgi Apparatus,Mitochondrion,Transcriptional Misregulation in Cancer
Research Areas (Faceted)
cancer,cell_biology,transcription_translation
Species
human
Target Sentence
GOLPH3 is a phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H4A6].
UniGene ID
Hs.408909
UniProt ID (eCommerce)
Q9H4A6
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.