human GMEB1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human GMEB1.
shADV-210034
Ad-h-GMEB1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human GMEB1 (glucocorticoid modulatory element binding protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DNA-binding protein p96PIF; glucocorticoid modulatory element-binding protein 1; GMEB-1; P96PIF; parvovirus initiation factor p96; PIF p96; PIF96
Description (eCommerce)
Glucocorticoid modulatory element-binding protein 1 (GMEB1) is a trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. GMEB also binds also to the transferrin receptor promoter. It is an essential auxiliary factor for the replication of parvoviruses [taken from the Universal Protein Resource (UniProt) ww.uniprot.org/uniprot/Q9Y692].
Description (Vector)
GMEB1 encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist.
Gene ID
10691
Gene Name (eCommerce)
glucocorticoid modulatory element binding protein 1
Gene Name (Vector)
glucocorticoid modulatory element binding protein 1
Gene Symbol
GMEB1
HGNC ID
HGNC:4370
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1692
ORF Size (bp)
1692 bp
Protein Name (eCommerce)
Glucocorticoid modulatory element-binding protein 1
RefSeq ID
NM_006582
RefSeq Synonyms
NM_024482, NM_006582, NM_001319674, BC001473,
Research Areas
Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Glucocorticoid modulatory element-binding protein 1 (GMEB1) is a trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. GMEB also binds also to the transferrin receptor promoter. It is an essential auxiliary factor for the replication of parvoviruses [taken from the Universal Protein Resource (UniProt) ww.uniprot.org/uniprot/Q9Y692].
UniGene ID
Hs.632373
UniProt ID (eCommerce)
Q9Y692
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.