human GLUD1 shRNA silencing Adenovirus

Name 
Ad-h-GLUD1-shRNA
Cat No 
shADV-210018
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human GLUD1.

shADV-210018
Ad-h-GLUD1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GLUD1 (glutamate dehydrogenase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
GDH; GDH1; GLUD
Description (Vector)
GLUD1 encodes glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.
Gene ID
2746
Gene Name (Vector)
glutamate dehydrogenase 1
Gene Symbol
GLUD1
HGNC ID
HGNC:4335
ORF Size (aa)
1677
ORF Size (bp)
1677 bp
RefSeq ID
NM_005271
RefSeq Synonyms
NM_005271, NM_001318906, NM_001318905, NM_001318904, NM_001318902, NM_001318901, NM_001318900, BC112946, BC040132,
Species
human
UniGene ID
Hs.500409

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.