human GLRX3 shRNA silencing Adenovirus

Name 
Ad-h-GLRX3-shRNA
Cat No 
shADV-209999
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human GLRX3.

shADV-209999
Ad-h-GLRX3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GLRX3 (glutaredoxin 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
GLRX4; glutaredoxin 4; glutaredoxin-3; GRX3; GRX4; PICOT; PKC-interacting cousin of thioredoxin; PKCq-interacting protein; PKC-theta-interacting protein; testicular tissue protein Li 75; thioredoxin-like protein 2; TXNL2; TXNL3
Description (eCommerce)
The gene GLRX3 encodes for the protein, Glutaredoxin-3. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. Glutaredoxin-3 may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer [taken from NCBI Entrez Gene (Gene ID: 10539)].
Description (Vector)
GLRX3 encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene.
Gene ID
10539
Gene Name (eCommerce)
glutaredoxin 3
Gene Name (Vector)
glutaredoxin 3
Gene Symbol
GLRX3
HGNC ID
HGNC:15987
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1008
ORF Size (bp)
1008 bp
Protein Name (eCommerce)
Glutaredoxin-3
RefSeq ID
NM_006541
RefSeq Synonyms
NM_006541, NM_001321980, NM_001199868, BC014372, BC005289,
Research Areas
Cardiac Hypertrophy,Cardiology,Cardiovascular
Research Areas (Faceted)
cardiovascular
Species
human
Target Sentence
The gene GLRX3 encodes for the protein, Glutaredoxin-3. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. Glutaredoxin-3 may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer [taken from NCBI Entrez Gene (Gene ID: 10539)].
UniGene ID
Hs.42644
UniProt ID (eCommerce)
O76003

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.