human GLRB shRNA silencing Adenovirus

Name
Ad-h-GLRB-shRNA

Cat No
shADV-209994

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human GLRB.

shADV-209994

Ad-h-GLRB-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GLRB (glycine receptor beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

HKPX2

Description (Vector)

GLRB encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.

Gene ID

2743

Gene Name (Vector)

glycine receptor beta

Gene Symbol

GLRB

HGNC ID

HGNC:4329

ORF Size (aa)

1494

ORF Size (bp)

1494 bp

RefSeq ID

NM_000824

RefSeq Synonyms

NM_001166061, NM_001166060, NM_000824, BC032635,

Species

human

UniGene ID

Hs.32973

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.