human GLI2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human GLI2.
shADV-209966
Ad-h-GLI2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human GLI2 (GLI family zinc finger 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CJS; GLI family zinc finger protein 2; GLI-Kruppel family member GLI2; glioma-associated oncogene family zinc finger 2; HPE9; oncogene GLI2; PHS2; Tax helper protein; tax helper protein 1; tax helper protein 2; tax-responsive element-2 holding protein; tax-responsive element-25-bp sequence binding protein; THP1; THP2; zinc finger protein GLI2
Description (eCommerce)
GLI2 functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992). GLI2 may also function as transcriptional repressor (By similarity). It requires STK36 for full transcriptional activator activity. GLI2 is required for normal embryonic development (PubMed:15994174, PubMed:20685856) [taken from NCBI Entrez Gene (Gene ID: 2736)].
Description (Vector)
GLI2 encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.
Gene ID
2736
Gene Name (eCommerce)
GLI family zinc finger 2
Gene Name (Vector)
GLI family zinc finger 2
Gene Symbol
GLI2
HGNC ID
HGNC:4318
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4761
ORF Size (bp)
4761 bp
Protein Name (eCommerce)
Zinc finger protein GLI2
RefSeq ID
NM_005270
RefSeq Synonyms
NM_005270, BC172434,
Research Areas
Apoptosis,Axon Guidance,Brain Development,Cancer,Cardiac Development,Cardiology,Cardiovascular,Hedgehog Signaling,Hippo Signaling,Immunology,Neurobiology,Neurodevelopment,Signal Transduction,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
GLI2 functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992). GLI2 may also function as transcriptional repressor (By similarity). It requires STK36 for full transcriptional activator activity. GLI2 is required for normal embryonic development (PubMed:15994174, PubMed:20685856) [taken from NCBI Entrez Gene (Gene ID: 2736)].
UniGene ID
Hs.111867
UniProt ID (eCommerce)
P10070
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.