human GJB6 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human GJB6.
shADV-209929
Ad-h-GJB6-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human GJB6 (gap junction protein beta 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CX30; DFNA3; DFNA3B; DFNB1B; ECTD2; ED2; EDH; HED; HED2
Description (Vector)
Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.
Gene ID
10804
Gene Name (Vector)
gap junction protein beta 6
Gene Symbol
GJB6
HGNC ID
HGNC:4288
ORF Size (aa)
786
ORF Size (bp)
786 bp
RefSeq ID
NM_006783
RefSeq Synonyms
NM_006783, NM_001110221, NM_001110220, NM_001110219, BC038934,
Species
human
UniGene ID
Hs.716216
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.