human GINS4 shRNA silencing Adenovirus

Name 
Ad-h-GINS4-shRNA
Cat No 
shADV-209894
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human GINS4.

shADV-209894
Ad-h-GINS4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GINS4 (GINS complex subunit 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DNA replication complex GINS protein SLD5; GINS complex subunit 4; SLD5; SLD5 homolog
Description (eCommerce)
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. The GINS complex seems to bind preferentially to single-stranded DNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BRT9].
Description (Vector)
The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 (PubMed 16287864)). See GINS1 for additional information about the GINS complex.(supplied by OMIM, Mar 2008)
Gene ID
84296
Gene Name (eCommerce)
GINS complex subunit 4
Gene Name (Vector)
GINS complex subunit 4
Gene Symbol
GINS4
HGNC ID
HGNC:28226
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
672
Protein Name (eCommerce)
DNA replication complex GINS protein SLD5
RefSeq ID
NM_032336
RefSeq Synonyms
NM_032336, BC005995,
Research Areas
Cell Cycle,DNA Replication,Replication
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. The GINS complex seems to bind preferentially to single-stranded DNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BRT9].
UniGene ID
Hs.656996
UniProt ID (eCommerce)
Q9BRT9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.