human GALE shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human GALE.
shADV-209572
Ad-h-GALE-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human GALE (UDP-galactose-4-epimerase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
SDR1E1
Description (Vector)
GALE encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
Gene ID
2582
Gene Name (Vector)
UDP-galactose-4-epimerase
Gene Symbol
GALE
HGNC ID
HGNC:4116
ORF Size (aa)
1047
ORF Size (bp)
1047 bp
RefSeq ID
NM_000403
RefSeq Synonyms
NM_001127621, NM_001008216, NM_000403, BC050685, BC001273,
Species
human
UniGene ID
Hs.632380
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.