human G6PC shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human G6PC.
shADV-209478
Ad-h-G6PC-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human G6PC (glucose-6-phosphatase catalytic subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
G6Pase; G6PC1; G6PT; GSD1; GSD1a
Description (Vector)
Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.
Gene ID
2538
Gene Name (Vector)
glucose-6-phosphatase catalytic subunit
Gene Symbol
G6PC
HGNC ID
HGNC:4056
ORF Size (aa)
1074
ORF Size (bp)
1074 bp
RefSeq ID
NM_000151
RefSeq Synonyms
NM_001270397, NM_000151, BC136369, BC130478,
Species
human
UniGene ID
Hs.212293
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.