human FYCO1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human FYCO1.
shADV-209451
Ad-h-FYCO1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human FYCO1 (FYVE and coiled-coil domain containing 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CATC2; CTRCT18; FYVE and coiled-coil domain-containing protein 1; RUFY3; RUN and FYVE domain containing 3; ZFYVE7; zinc finger FYVE domain-containing protein 7
Description (eCommerce)
FYCO1 (FYVE and coiled-coil domain-containing protein 1) has been identified as a protein that interacts with LC3, Rab7 and PI3P. FYCO1 contains a FYVE-type zinc finger, one GOLD domain, and a RUN domain. FYCO1 is suggested to play a role in microtubule plus end-directed transport of autophagic vesicles.
Description (Vector)
FYCO1 encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2).
Gene ID
79443
Gene Name (eCommerce)
FYVE and coiled-coil domain containing 1
Gene Name (Vector)
FYVE and coiled-coil domain containing 1
Gene Symbol
FYCO1
HGNC ID
HGNC:14673
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4437
ORF Size (bp)
4437 bp
Protein Name (eCommerce)
FYVE and coiled-coil domain-containing protein 1
RefSeq ID
NM_024513
RefSeq Synonyms
NM_024513, BC101470, BC101468, BC007218,
Research Areas
Autophagy,Lysosome,Transport,Zinc-finger
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
FYCO1 (FYVE and coiled-coil domain-containing protein 1) has been identified as a protein that interacts with LC3, Rab7 and PI3P. FYCO1 contains a FYVE-type zinc finger, one GOLD domain, and a RUN domain. FYCO1 is suggested to play a role in microtubule plus end-directed transport of autophagic vesicles.
UniGene ID
Hs.714847
UniProt ID (eCommerce)
Q9BQS8
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.