human FMO3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human FMO3.
shADV-209182
Ad-h-FMO3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human FMO3 (flavin containing monooxygenase 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
dJ127D3.1; FMOII; TMAU
Description (Vector)
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.
Gene ID
2328
Gene Name (Vector)
flavin containing monooxygenase 3
Gene Symbol
FMO3
HGNC ID
HGNC:3771
ORF Size (aa)
1599
ORF Size (bp)
1599 bp
RefSeq ID
NM_001002294
RefSeq Synonyms
NM_006894, NM_001319174, NM_001319173, NM_001002294, BC032016,
Species
human
UniGene ID
Hs.445350
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.