human FGFR2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human FGFR2.
shADV-208995
Ad-h-FGFR2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human FGFR2 (fibroblast growth factor receptor 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25
Description (Vector)
FGFR2 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Gene ID
2263
Gene Name (Vector)
fibroblast growth factor receptor 2
Gene Symbol
FGFR2
HGNC ID
HGNC:3689
ORF Size (aa)
2115
ORF Size (bp)
2115 bp
RefSeq ID
NM_000141
RefSeq Synonyms
NM_023029, NM_022970, NM_001320658, NM_001320654, NM_001144919, NM_001144918, NM_001144917, NM_001144916, NM_001144915, NM_001144914, NM_001144913, NM_000141, BC039243,
Species
human
UniGene ID
Hs.533683
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.