human FGFR1OP shRNA silencing Adenovirus

Name 
Ad-h-FGFR1OP-shRNA
Cat No 
shADV-208993
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human FGFR1OP.

shADV-208993
Ad-h-FGFR1OP-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human FGFR1OP (FGFR1 oncogene partner). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
FGFR1 oncogene partner; fibroblast growth factor receptor 1 oncogene partner; FOP
Description (eCommerce)
FOP (FGFR1 Oncogene Partner) was identified and cloned as part of a translocation breakpoint in which the protein kinase domain of the FGFR1 (Fibroblast Growth Factor Receptor 1) gene is fused to the leucine-rich domain of FOP. Translocations involving FOP and FGFR1 are associated with stem cell myeloproliferative disorder (MPD). FOP has also been identified as a part of a centrosomal complex and has been shown to be required for the anchoring and organization of the microtubule network to subcellular structures.
Description (Vector)
FGFR1OP encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. FGFR1OP is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.
Gene ID
11116
Gene Name (eCommerce)
FGFR1 oncogene partner
Gene Name (Vector)
FGFR1 oncogene partner
Gene Symbol
FGFR1OP
HGNC ID
HGNC:17012
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1140
ORF Size (bp)
1140 bp
Protein Name (eCommerce)
FGFR1 oncogene partner
RefSeq ID
NM_007045
RefSeq Synonyms
NM_194429, NM_007045, NM_001278690, BC011902,
Research Areas
Cell Cycle,Cytoskeleton,FGF Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,signal_transduction
Species
human
Target Sentence
FOP (FGFR1 Oncogene Partner) was identified and cloned as part of a translocation breakpoint in which the protein kinase domain of the FGFR1 (Fibroblast Growth Factor Receptor 1) gene is fused to the leucine-rich domain of FOP. Translocations involving FOP and FGFR1 are associated with stem cell myeloproliferative disorder (MPD). FOP has also been identified as a part of a centrosomal complex and has been shown to be required for the anchoring and organization of the microtubule network to subcellular structures.
UniGene ID
Hs.487175
UniProt ID (eCommerce)
O95684

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.