human FDPS shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human FDPS.
shADV-208888
Ad-h-FDPS-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human FDPS (farnesyl diphosphate synthase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
(2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase; FPP synthase; FPP synthetase; FPPS; FPS; Geranyltranstransferase; POROK9
Description (eCommerce)
Farnesyl diphosphate synthase (FDPS) is a key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P14324].
Description (Vector)
FDPS encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
2224
Gene Name (eCommerce)
farnesyl diphosphate synthase
Gene Name (Vector)
farnesyl diphosphate synthase
Gene Symbol
FDPS
HGNC ID
HGNC:3631
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1260
ORF Size (bp)
1260 bp
Protein Name (eCommerce)
Farnesyl pyrophosphate synthase
RefSeq ID
NM_002004
RefSeq Synonyms
NM_002004, NM_001242825, NM_001242824, NM_001135822, NM_001135821, BC010004,
Research Areas
Host-Virus Interactions,Metabolism/Metabolic Process,Mitochondrion,Signal Transduction
Research Areas (Faceted)
signal_transduction,infectious_disease,metabolism,cell_biology
Species
human
Target Sentence
Farnesyl diphosphate synthase (FDPS) is a key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P14324].
UniGene ID
Hs.335918
UniProt ID (eCommerce)
P14324
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.