human FBXW8 shRNA silencing Adenovirus

Name
Ad-h-FBXW8-shRNA

Cat No
shADV-208842

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human FBXW8.

shADV-208842

Ad-h-FBXW8-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human FBXW8 (F-box and WD repeat domain containing 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

FBW6; FBW8; FBX29; FBXO29; FBXW6

Description (Vector)

FBXW8 encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Gene ID

26259

Gene Name (Vector)

F-box and WD repeat domain containing 8

Gene Symbol

FBXW8

HGNC ID

HGNC:13597

ORF Size (aa)

1797

ORF Size (bp)

1797 bp

RefSeq ID

NM_012174

RefSeq Synonyms

NM_153348, NM_012174, BC037296,

Species

human

UniGene ID

Hs.696428

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.