human FANCB shRNA silencing Adenovirus

Name 
Ad-h-FANCB-shRNA
Cat No 
shADV-208692
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human FANCB.

shADV-208692
Ad-h-FANCB-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human FANCB (Fanconi anemia complementation group B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
FA2; FAAP90; FAAP95; FAB; FACB; Fanconi anemia complementation group B; Fanconi anemia group B protein; Fanconi anemia-associated polypeptide of 95 kDa; Protein FACB
Description (eCommerce)
FANCB (Fanconi anemia complementation group B) is part of a DNA repair network which involves BRCA1 and BRCA2 and required for the ubiquitination of FANCD2. The FANCB gene is one of 13 complementation groups that include FANCA, FANCB, FANCC, FANCD1/BRCA2, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ/BRIP1, FANCL, FANCM, and FANCN/PALB2. The FANC members are not homologous proteins but are related by their assembly into a common nuclear complex. Defects in FANCB are the cause of Fanconi pancytopenia type 2, Fanconi anemia, and X-linked VACTERL.
Description (Vector)
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group B. Alternative splicing results in two transcript variants encoding the same protein.
Gene ID
2187
Gene Name (eCommerce)
FA complementation group B
Gene Name (Vector)
Fanconi anemia complementation group B
Gene Symbol
FANCB
HGNC ID
HGNC:3583
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2580
ORF Size (bp)
2580 bp
Protein Name (eCommerce)
Fanconi anemia group B protein
RefSeq ID
NM_152633
RefSeq Synonyms
NM_152633, NM_001324162, NM_001018113, BC136560, BC136558,
Research Areas
DNA Damage/Repair,Fanconi anemia
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
FANCB (Fanconi anemia complementation group B) is part of a DNA repair network which involves BRCA1 and BRCA2 and required for the ubiquitination of FANCD2. The FANCB gene is one of 13 complementation groups that include FANCA, FANCB, FANCC, FANCD1/BRCA2, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ/BRIP1, FANCL, FANCM, and FANCN/PALB2. The FANC members are not homologous proteins but are related by their assembly into a common nuclear complex. Defects in FANCB are the cause of Fanconi pancytopenia type 2, Fanconi anemia, and X-linked VACTERL.
UniGene ID
Hs.554740
UniProt ID (eCommerce)
Q8NB91

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.