human RPL5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RPL5.
shADV-208616
Ad-h-RPL5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RPL5 (ribosomal protein L5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
60S ribosomal protein L5; L5; large ribosomal subunit protein uL18; MSTP030; PPP1R135; protein phosphatase 1, regulatory subunit 135; uL18
Description (eCommerce)
Ribosomal protein L5 (RPL5) is required for rRNA maturation and formation of the 60S ribosomal subunits. RPL5 binds 5S RNA. Defects in the RPL5 gene are the cause of Diamond-Blackfan anemia type 6 (DBA6), a congenital non-regenerative hypoplastic anemia that usually presents early in infancy [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P46777].
Description (Vector)
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18P family of ribosomal proteins. It is located in the cytoplasm. The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The protein interacts specifically with the beta subunit of casein kinase II. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Gene ID
6125
Gene Name (eCommerce)
ribosomal protein L5
Gene Name (Vector)
ribosomal protein L5
Gene Symbol
RPL5
HGNC ID
HGNC:10360
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
894
Protein Name (eCommerce)
60S ribosomal protein L5
RefSeq ID
NM_000969
RefSeq Synonyms
NM_000969, BC132972, BC132970, BC109370, BC001882,
Research Areas
Gene Expression,Host-Virus Interactions,Kinase/Phosphatase,Metabolism/Metabolic Process,p53 Signaling,RNA Binding,RNA Processing,Signal Transduction,Translational Control
Research Areas (Faceted)
signal_transduction,genetics,transcription_translation,infectious_disease,cell_biology,metabolism,signal_transduction,genetics,transcription_translation
Species
human
Target Sentence
Ribosomal protein L5 (RPL5) is required for rRNA maturation and formation of the 60S ribosomal subunits. RPL5 binds 5S RNA. Defects in the RPL5 gene are the cause of Diamond-Blackfan anemia type 6 (DBA6), a congenital non-regenerative hypoplastic anemia that usually presents early in infancy [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P46777].
UniGene ID
Hs.180946
UniProt ID (eCommerce)
P46777
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.