human EZH2 shRNA silencing Adenovirus

Name 
Ad-h-EZH2-shRNA
Cat No 
shADV-208212
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EZH2.

shADV-208212
Ad-h-EZH2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
enhancer of zeste homolog 2; ENX1; ENX-1; EZH2b; histone-lysine N-methyltransferase EZH2; KMT6; KMT6A; lysine N-methyltransferase 6; WVS; WVS2
Description (eCommerce)
Enhancer of zeste homolog 2 (EZH2) is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play a role in the hematopoietic and central nervous systems [taken from NCBI Entrez Gene (Gene ID: 2146)].
Description (Vector)
EZH2 encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
Gene ID
2146
Gene Name (eCommerce)
enhancer of zeste 2 polycomb repressive complex 2 subunit
Gene Name (Vector)
enhancer of zeste 2 polycomb repressive complex 2 subunit
Gene Symbol
EZH2
HGNC ID
HGNC:3527
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2256
ORF Size (bp)
2256 bp
Protein Name (eCommerce)
Histone-lysine N-methyltransferase EZH2
RefSeq ID
NM_004456
RefSeq Synonyms
NM_152998, NM_004456, NM_001203249, NM_001203248, NM_001203247, BC010858,
Research Areas
Cancer,Cell Cycle,Chromatin Remodeling,Complexome,Epigenetic Regulation of Gene Expression,Histone Modification,Immunology,Methyltransferase,MicroRNAs in Cancer,Neurobiology,Neurodevelopment,Phospho-specific,Polycomb Proteins,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,neurobiology,stem_cell_biology
Species
human
Target Sentence
Enhancer of zeste homolog 2 (EZH2) is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play a role in the hematopoietic and central nervous systems [taken from NCBI Entrez Gene (Gene ID: 2146)].
UniGene ID
Hs.444082
UniProt ID (eCommerce)
Q15910

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.