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human EXOSC4 shRNA silencing Adenovirus

Name 
Ad-h-EXOSC4-shRNA
Cat No 
shADV-208191
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EXOSC4.

shADV-208191
Ad-h-EXOSC4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EXOSC4 (exosome component 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
exosome complex component RRP41; exosome complex exonuclease RRP41; Exosome component 4; exosome component Rrp41; hRrp41p; p12A; ribosomal RNA-processing protein 41; RRP41; RRP41A; Rrp41p; SKI6; Ski6p
Description (eCommerce)
Exosome component 4 (EXOSC4) is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NPD3].
Gene ID
54512
Gene Name (eCommerce)
exosome component 4
Gene Name (Vector)
exosome component 4
Gene Symbol
EXOSC4
HGNC ID
HGNC:18189
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
738
ORF Size (bp)
738 bp
Protein Name (eCommerce)
Exosome complex component RRP41
RefSeq ID
NM_019037
RefSeq Synonyms
NM_019037, BC002777,
Research Areas
Gene Expression,Host-Virus Interactions,mRNA Binding,Response to Virus,RNA Binding,RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,immunology,infectious_disease,transcription_translation
Species
human
Target Sentence
Exosome component 4 (EXOSC4) is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NPD3].
UniGene ID
Hs.632041
UniProt ID (eCommerce)
Q9NPD3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.