human EXOSC2 shRNA silencing Adenovirus

Name 
Ad-h-EXOSC2-shRNA
Cat No 
shADV-208188
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EXOSC2.

shADV-208188
Ad-h-EXOSC2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EXOSC2 (exosome component 2). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
exosome complex component RRP4; exosome complex exonuclease RRP4; Exosome component 2; homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5' exoribonuclease (RRP4); homolog of yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease; hRrp4p; p7; ribosomal RNA-processing protein 4; RRP4; Rrp4p; SHRF
Description (eCommerce)
EXOSC2 is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13868].
Gene ID
23404
Gene Name (eCommerce)
exosome component 2
Gene Name (Vector)
exosome component 2
Gene Symbol
EXOSC2
HGNC ID
HGNC:17097
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
882
ORF Size (bp)
882 bp
Protein Name (eCommerce)
Exosome complex component RRP4
RefSeq ID
NM_014285
RefSeq Synonyms
NM_014285, NM_001282709, NM_001282708, BC000747,
Research Areas
Gene Expression,mRNA Binding,RNA Binding,RNA Processing
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
EXOSC2 is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13868].
UniGene ID
Hs.654643
UniProt ID (eCommerce)
Q13868

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.