human ESRRG shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ESRRG.
shADV-208125
Ad-h-ESRRG-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ESRRG (estrogen related receptor gamma). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ERR3; ERRgamma; NR3B3
Description (Vector)
ESRRG encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.
Gene ID
2104
Gene Name (Vector)
estrogen related receptor gamma
Gene Symbol
ESRRG
HGNC ID
HGNC:3474
ORF Size (aa)
1329
ORF Size (bp)
1329 bp
RefSeq ID
NM_206595
RefSeq Synonyms
NM_206595, NM_206594, NM_001438, NM_001243519, NM_001243518, NM_001243515, NM_001243514, NM_001243513, NM_001243512, NM_001243511, NM_001243510, NM_001243509, NM_001243507, NM_001243506, NM_001243505, NM_001134285, BC064700,
Species
human
UniGene ID
Hs.444225
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.