human EPS15 shRNA silencing Adenovirus

Name
Ad-h-EPS15-shRNA

Cat No
shADV-208021

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human EPS15.

shADV-208021

Ad-h-EPS15-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EPS15 (epidermal growth factor receptor pathway substrate 15). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

AF1P; AF-1P; ALL1 fused gene from chromosome 1; epidermal growth factor receptor substrate 15; MLLT5; protein AF-1p; Protein Eps15

Description (eCommerce)

EPS15 (epidermal growth factor receptor substrate 15) is a protein phosphorylated by the EGF receptor and involved in the internalization of the EGF-receptor via clathrin-coated pits.

Description (Vector)

EPS15 encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene ID

2060

Gene Name (eCommerce)

epidermal growth factor receptor pathway substrate 15

Gene Name (Vector)

epidermal growth factor receptor pathway substrate 15

Gene Symbol

EPS15

HGNC ID

HGNC:3419

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2289

ORF Size (bp)

2289 bp

Protein Name (eCommerce)

Epidermal growth factor receptor substrate 15

RefSeq ID

NM_001981

RefSeq Synonyms

NM_001981, NM_001159969, BC054006,

Research Areas

Cancer,EGFR Signaling,EGFR Signaling in Cancer,HGF Signaling,Notch Signaling,Signal Transduction

Research Areas (Faceted)

cancer,developmental_biology,signal_transduction

Species

human

Target Sentence

EPS15 (epidermal growth factor receptor substrate 15) is a protein phosphorylated by the EGF receptor and involved in the internalization of the EGF-receptor via clathrin-coated pits.

UniGene ID

Hs.83722

UniProt ID (eCommerce)

P42566

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.