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human EPRS shRNA silencing Adenovirus

Name 
Ad-h-EPRS-shRNA
Cat No 
shADV-208019
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EPRS.

shADV-208019
Ad-h-EPRS-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EPRS (glutamyl-prolyl-tRNA synthetase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
bifunctional aminoacyl-tRNA synthetase; bifunctional glutamate/proline--tRNA ligase; cell proliferation-inducing gene 32 protein; EARS; GLUPRORS; GluRS; glutamate tRNA ligase; Glutamate--tRNA ligase; glutamatyl-prolyl-tRNA synthetase; glutaminyl-tRNA synthetase; Glutamyl-tRNA synthetase; HLD15; PARS; PIG32; proliferation-inducing gene 32 protein; proliferation-inducing protein 32; proline-tRNA ligase; Proline--tRNA ligase; prolyl-tRNA synthetase; QARS; QPRS
Description (eCommerce)
EPRS (glutamyl-prolyl-tRNA synthetase) catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P07814].
Description (Vector)
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined.
Gene ID
2058
Gene Name (eCommerce)
glutamyl-prolyl-tRNA synthetase
Gene Name (Vector)
glutamyl-prolyl-tRNA synthetase
Gene Symbol
EPRS
HGNC ID
HGNC:3418
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4539
ORF Size (bp)
4539 bp
Protein Name (eCommerce)
Bifunctional glutamate/proline--tRNA ligase
RefSeq ID
NM_004446
RefSeq Synonyms
NM_004446, BC136465, BC126275,
Research Areas
Gene Expression,Immunology,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,Parkinson's Disease,RNA Binding,RNA Processing,T-cell Receptor Signaling,Translational Control
Research Areas (Faceted)
cell_biology,genetics,immunology,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
EPRS (glutamyl-prolyl-tRNA synthetase) catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P07814].
UniGene ID
Hs.497788
UniProt ID (eCommerce)
P07814

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.