human EPCAM shRNA silencing Adenovirus

Name 
Ad-h-EPCAM-shRNA
Cat No 
shADV-207971
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EPCAM.

shADV-207971
Ad-h-EPCAM-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EPCAM (epithelial cell adhesion molecule). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
adenocarcinoma-associated antigen; CD antigen CD326; cell surface glycoprotein Trop-1; DIAR5; EGP; EGP-2; EGP314; EGP40; Ep-CAM; epithelial cell adhesion molecule; Epithelial cell surface antigen; Epithelial glycoprotein; epithelial glycoprotein 314; ESA; hEGP314; HNPCC8; human epithelial glycoprotein-2; KS 1/4 antigen; KS1/4; KSA; M4S1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein); MIC18; MK-1; TACSTD1; TROP1; tumor-associated calcium signal transducer 1
Description (eCommerce)
EpCAM, or epithelial cell adhesion molecule, is a type I transmembrane protein expressed on most normal epithelial cells and gastrointestinal carcinomas. It functions as a homotypic calcium-independent cell adhesion molecule. EpCAM is being used as a target for immunotherapy treatment of some human carcinomas [taken from NCBI Entrez Gene (Gene ID: 4072)].
Description (Vector)
EPCAM encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.
Gene ID
4072
Gene Name (eCommerce)
epithelial cell adhesion molecule
Gene Name (Vector)
epithelial cell adhesion molecule
Gene Symbol
EPCAM
HGNC ID
HGNC:11529
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
945
ORF Size (bp)
945 bp
Protein Name (eCommerce)
Epithelial cell adhesion molecule
RefSeq ID
NM_002354
RefSeq Synonyms
NM_002354, BC014785,
Research Areas
Cancer,Colorectal Cancer,Signal Transduction
Research Areas (Faceted)
cancer,signal_transduction
Species
human
Target Sentence
EpCAM, or epithelial cell adhesion molecule, is a type I transmembrane protein expressed on most normal epithelial cells and gastrointestinal carcinomas. It functions as a homotypic calcium-independent cell adhesion molecule. EpCAM is being used as a target for immunotherapy treatment of some human carcinomas [taken from NCBI Entrez Gene (Gene ID: 4072)].
UniGene ID
Hs.542050
UniProt ID (eCommerce)
P16422

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.