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human ELAC2 shRNA silencing Adenovirus

Name 
Ad-h-ELAC2-shRNA
Cat No 
shADV-207826
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ELAC2.

shADV-207826
Ad-h-ELAC2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ELAC2 (elaC ribonuclease Z 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
COXPD17; elaC homolog 2; elaC homolog protein 2; elaC-like protein 2; ELC2; heredity prostate cancer protein 2; HPC2; putative prostate cancer susceptibility protein HPC2/ELAC2; ribonuclease Z 2; RNase Z 2; tRNA 3 endonuclease 2; tRNase Z (long form); tRNase Z 2; zinc phosphodiesterase ELAC protein 2
Description (eCommerce)
ELAC2 is a zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity.It is involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BQ52].
Description (Vector)
ELAC2 has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
60528
Gene Name (eCommerce)
elaC ribonuclease Z 2
Gene Name (Vector)
elaC ribonuclease Z 2
Gene Symbol
ELAC2
HGNC ID
HGNC:14198
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2481
ORF Size (bp)
2481 bp
Protein Name (eCommerce)
Zinc phosphodiesterase ELAC protein 2
RefSeq ID
NM_018127
RefSeq Synonyms
NM_173717, NM_018127, NM_001165962, BC004158, BC001939,
Research Areas
Cancer,Mitochondrion,RNA Processing,RNA Transport
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
ELAC2 is a zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity.It is involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BQ52].
UniGene ID
Hs.434232
UniProt ID (eCommerce)
Q9BQ52

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.