human ELA2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ELANE.
shADV-207815
Ad-h-ELA2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ELANE (elastase, neutrophil expressed). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ELA2; GE; HLE; HNE; NE; PMN-E; SCN1
Description (Vector)
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
Gene ID
1991
Gene Name (Vector)
elastase, neutrophil expressed
Gene Symbol
ELANE
HGNC ID
HGNC:3309
ORF Size (aa)
804
ORF Size (bp)
804 bp
RefSeq ID
NM_001972
RefSeq Synonyms
NM_001972, BC074817, BC074816,
Species
human
UniGene ID
Hs.99863
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.