Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human EIF3K shRNA silencing Adenovirus

Name 
Ad-h-EIF3K-shRNA
Cat No 
shADV-207758
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EIF3K.

shADV-207758
Ad-h-EIF3K-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EIF3K (eukaryotic translation initiation factor 3 subunit K). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ARG134; eIF-3 p25; eIF-3 p28; eIF3k; EIF3-p28; EIF3S12; Eukaryotic translation initiation factor 3 subunit 12; eukaryotic translation initiation factor 3 subunit K; eukaryotic translation initiation factor 3, subunit 12; HSPC029; M9; MSTP001; muscle specific; muscle-specific gene M9 protein; PLAC24; PLAC-24; PRO1474; PTD001
Description (eCommerce)
Eukaryotic initiation factor 3 subunit K (eIf3K) is one of at least 13 non-identical protein subunits of eukaryotic initiation factor 3 (eIF3). eIF3 is the largest eIF (~650 kDa) and functions to facilitate binding of the 40S ribosomal subunit to the 5’-end of cellular mRNAs near the cap structure (m7GpppN). eIF3 has been found to localize to both the nucleus and cytoplasm. In the cytoplasm, eIf3K associates with keratin 18 in intermediate filaments of epithelial cells and may have an apoptosis-promoting function. It also has been shown to interact with cyclin D3.
Description (Vector)
The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 (PubMed 14519125)).(supplied by OMIM, Mar 2008)
Gene ID
27335
Gene Name (eCommerce)
eukaryotic translation initiation factor 3 subunit K
Gene Name (Vector)
eukaryotic translation initiation factor 3 subunit K
Gene Symbol
EIF3K
HGNC ID
HGNC:24656
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
657
Protein Name (eCommerce)
Eukaryotic translation initiation factor 3 subunit K
RefSeq ID
NM_013234
RefSeq Synonyms
NM_013234, NM_001308393, NM_001300992, BC007559, BC001031,
Research Areas
Gene Expression,Metabolism/Metabolic Process,mRNA Binding,Translational Control
Research Areas (Faceted)
cell_biology,genetics,metabolism,transcription_translation
Species
human
Target Sentence
Eukaryotic initiation factor 3 subunit K (eIf3K) is one of at least 13 non-identical protein subunits of eukaryotic initiation factor 3 (eIF3). eIF3 is the largest eIF (~650 kDa) and functions to facilitate binding of the 40S ribosomal subunit to the 5’-end of cellular mRNAs near the cap structure (m7GpppN). eIF3 has been found to localize to both the nucleus and cytoplasm. In the cytoplasm, eIf3K associates with keratin 18 in intermediate filaments of epithelial cells and may have an apoptosis-promoting function. It also has been shown to interact with cyclin D3.
UniGene ID
Hs.314359
UniProt ID (eCommerce)
Q9UBQ5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.