human EIF3H shRNA silencing Adenovirus

Name 
Ad-h-EIF3H-shRNA
Cat No 
shADV-207754
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EIF3H.

shADV-207754
Ad-h-EIF3H-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EIF3H (eukaryotic translation initiation factor 3 subunit H). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
eIF3 p40 subunit; eIF-3-gamma; eIF3-gamma; eIF3h; eIF3-p40; EIF3S3; eukaryotic translation initiation factor 3 subunit 3; eukaryotic translation initiation factor 3 subunit H; eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD); eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD); eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa
Description (eCommerce)
Eukaryotic initiation factor 3 subunit H (eIF3H) is one of at least 13 non-identical protein subunits of eukaryotic initiation factor 3 (eIF3). eIF3 is the largest eIF (~650 kDa) and functions to facilitate binding of the 40S ribosomal subunit to the 5’-end of cellular mRNAs near the cap structure (m7GpppN). eIF3H is a non-conserved subunit and part of the functional core of eIF3. It may function to stabilize the eIF3 complex and stimulate protein synthesis. Many cancer cell lines have been shown to express high levels of eIF3H, and it may have an oncogenic role in colorectal cancer susceptibility.
Gene ID
8667
Gene Name (eCommerce)
eukaryotic translation initiation factor 3 subunit H
Gene Name (Vector)
eukaryotic translation initiation factor 3 subunit H
Gene Symbol
EIF3H
HGNC ID
HGNC:3273
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1050
ORF Size (bp)
1050 bp
Protein Name (eCommerce)
Eukaryotic translation initiation factor 3 subunit H
RefSeq ID
NM_003756
RefSeq Synonyms
NM_003756, BC090880, BC000386,
Research Areas
Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,mRNA Binding,RNA Transport,Translational Control
Research Areas (Faceted)
genetics,transcription_translation,infectious_disease,metabolism,genetics,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Eukaryotic initiation factor 3 subunit H (eIF3H) is one of at least 13 non-identical protein subunits of eukaryotic initiation factor 3 (eIF3). eIF3 is the largest eIF (~650 kDa) and functions to facilitate binding of the 40S ribosomal subunit to the 5’-end of cellular mRNAs near the cap structure (m7GpppN). eIF3H is a non-conserved subunit and part of the functional core of eIF3. It may function to stabilize the eIF3 complex and stimulate protein synthesis. Many cancer cell lines have been shown to express high levels of eIF3H, and it may have an oncogenic role in colorectal cancer susceptibility.
UniGene ID
Hs.492599
UniProt ID (eCommerce)
O15372

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.