human EIF2S1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human EIF2S1.
shADV-207726
Ad-h-EIF2S1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha; eIF-2-alpha; eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Description (eCommerce)
eIF-2alpha is the alpha subunit of the eukaryotic initiation factor 2. The EIF2 forms a ternary complex with GTP and initiator Met-tRNAi and is responsible for the binding of initiator Met-tRNAi and mRNA to 40S ribosomes for protein synthesis.
Description (Vector)
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 (PubMed 2948954)).(supplied by OMIM, Feb 2010)
Gene ID
1965
Gene Name (eCommerce)
eukaryotic translation initiation factor 2 subunit alpha
Gene Name (Vector)
eukaryotic translation initiation factor 2 subunit alpha
Gene Symbol
EIF2S1
HGNC ID
HGNC:3265
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
948
Protein Name (eCommerce)
Eukaryotic translation initiation factor 2 subunit 1
RefSeq ID
NM_004094
RefSeq Synonyms
NM_004094, BC002513,
Research Areas
BDNF Signaling,Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,mRNA Binding,mTOR Signaling,Neurobiology,Protein Folding,RNA Binding,RNA Transport,Signal Transduction,Translational Control
Research Areas (Faceted)
cell_biology,genetics,infectious_disease,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
eIF-2alpha is the alpha subunit of the eukaryotic initiation factor 2. The EIF2 forms a ternary complex with GTP and initiator Met-tRNAi and is responsible for the binding of initiator Met-tRNAi and mRNA to 40S ribosomes for protein synthesis.
UniGene ID
Hs.151777
UniProt ID (eCommerce)
P05198
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.