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human EFTUD2 shRNA silencing Adenovirus

Name 
Ad-h-EFTUD2-shRNA
Cat No 
shADV-207654
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EFTUD2.

shADV-207654
Ad-h-EFTUD2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EFTUD2 (elongation factor Tu GTP binding domain containing 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
116 kDa U5 small nuclear ribonucleoprotein component; elongation factor Tu GTP-binding domain-containing protein 2; hSNU114; MFDGA; MFDM; SNRNP116; Snrp116; Snu114; SNU114 homolog; U5 snRNP-specific protein, 116 kDa; U5-116 kDa; U5-116KD
Description (eCommerce)
The splicesome is the molecular machine responsible for catalyzing intron removal from pre-mRNA transcripts. The splicesome is composed of several small nuclear RNAs (snRNAs) complexed with their associated proteins [together termed snRNPs (small nuclear ribonucleoprotein)]. One of the major classes of snRNPs includes the U1, U2, U4, U5 and U6 snRNP. EFTUD2/SNRP116 is a component of the U5 snRNP. EFTUD2/SNRP116 is a GTPase that may play a role in disrupting U4/U6 helices prior to splicesome activation.
Description (Vector)
EFTUD2 encodes a GTPase which is a component of the spliceosome complex which processes precursor mRNAs to produce mature mRNAs. Mutations in this gene are associated with mandibulofacial dysostosis with microcephaly. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
9343
Gene Name (eCommerce)
elongation factor Tu GTP binding domain containing 2
Gene Name (Vector)
elongation factor Tu GTP binding domain containing 2
Gene Symbol
EFTUD2
HGNC ID
HGNC:30858
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2919
ORF Size (bp)
2919 bp
Protein Name (eCommerce)
116 kDa U5 small nuclear ribonucleoprotein component
RefSeq ID
NM_004247
RefSeq Synonyms
NM_004247, NM_001258354, NM_001258353, NM_001142605, BC002360,
Research Areas
Gene Expression,mRNA Processing,mRNA Splicing,Neurobiology,RNA Processing,Spliceosome
Research Areas (Faceted)
genetics,transcription_translation,neurobiology,cell_biology
Species
human
Target Sentence
The splicesome is the molecular machine responsible for catalyzing intron removal from pre-mRNA transcripts. The splicesome is composed of several small nuclear RNAs (snRNAs) complexed with their associated proteins [together termed snRNPs (small nuclear ribonucleoprotein)]. One of the major classes of snRNPs includes the U1, U2, U4, U5 and U6 snRNP. EFTUD2/SNRP116 is a component of the U5 snRNP. EFTUD2/SNRP116 is a GTPase that may play a role in disrupting U4/U6 helices prior to splicesome activation.
UniGene ID
Hs.151787
UniProt ID (eCommerce)
Q15029

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.