human ECT2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ECT2.
shADV-207545
Ad-h-ECT2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ECT2 (epithelial cell transforming 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ARHGEF31; epithelial cell-transforming sequence 2 oncogene; protein ECT2
Description (eCommerce)
Epithelial cell-transforming sequence 2 (ECT2) is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis [taken from NCBI GeneID:1894].
Description (Vector)
ECT2 is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding two different isoforms have been found for this gene.
Gene ID
1894
Gene Name (eCommerce)
epithelial cell transforming 2
Gene Name (Vector)
epithelial cell transforming 2
Gene Symbol
ECT2
HGNC ID
HGNC:3155
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2652
ORF Size (bp)
2652 bp
Protein Name (eCommerce)
Protein ECT2
RefSeq ID
NM_018098
RefSeq Synonyms
NM_018098, NM_001258316, NM_001258315, BC112086,
Research Areas
Apoptosis,Cancer,Cell Cycle,Cell Division,Cytoskeleton,GPCR Signaling,Neurobiology,Neurodevelopment,Neurogenesis,NF-kB Signaling,NGF Signaling,PLK1 Signaling,Rho Signaling,Signal Transduction,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,neurobiology,signal_transduction
Species
human
Target Sentence
Epithelial cell-transforming sequence 2 (ECT2) is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis [taken from NCBI GeneID:1894].
UniGene ID
Hs.518299
UniProt ID (eCommerce)
Q9H8V3
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.