human DNASE2 shRNA silencing Adenovirus

Name
Ad-h-DNASE2-shRNA

Cat No
shADV-207192

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human DNASE2.

shADV-207192

Ad-h-DNASE2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DNASE2 (deoxyribonuclease 2, lysosomal). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

DNASE2A; DNL; DNL2

Description (Vector)

DNASE2 encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.

Gene ID

1777

Gene Name (Vector)

deoxyribonuclease 2, lysosomal

Gene Symbol

DNASE2

HGNC ID

HGNC:2960

ORF Size (aa)

1083

ORF Size (bp)

1083 bp

RefSeq ID

NM_001375

RefSeq Synonyms

NM_001375, BC065209, BC010419,

Species

human

UniGene ID

Hs.118243

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.