human DMAP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human DMAP1.
shADV-207077
Ad-h-DMAP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human DMAP1 (DNA methyltransferase 1 associated protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DNA methyltransferase 1-associated protein 1; DNMAP1; DNMT1 associated protein 1; DNMT1-associated protein 1; DNMTAP1; EAF2; MEAF2; SWC4
Description (eCommerce)
DMAP1 (DNA methyltransferase 1 associated protein 1) has been identified as a subunit of several distinct protein complexes involved in the repression and activation of transcription. It has been observed to interact with histone deacetylase 2 (HDAC2) as well as histone acetyltransferase (HAT) indicating a role in nucleosome modification to regulate transcription. DMAP1 can act independently to repress transcription in association with DNA methyltransferase 1.
Description (Vector)
DMAP1 encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.
Gene ID
55929
Gene Name (eCommerce)
DNA methyltransferase 1 associated protein 1
Gene Name (Vector)
DNA methyltransferase 1 associated protein 1
Gene Symbol
DMAP1
HGNC ID
HGNC:18291
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1404
ORF Size (bp)
1404 bp
Protein Name (eCommerce)
DNA methyltransferase 1-associated protein 1
RefSeq ID
NM_019100
RefSeq Synonyms
NM_019100, NM_001034024, NM_001034023, BC008053, BC002855,
Research Areas
Cell Cycle,Chromatin Remodeling,Histone Modification,Neurobiology,Replication,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,transcription_translation,genetics,neurobiology,cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
DMAP1 (DNA methyltransferase 1 associated protein 1) has been identified as a subunit of several distinct protein complexes involved in the repression and activation of transcription. It has been observed to interact with histone deacetylase 2 (HDAC2) as well as histone acetyltransferase (HAT) indicating a role in nucleosome modification to regulate transcription. DMAP1 can act independently to repress transcription in association with DNA methyltransferase 1.
UniGene ID
Hs.8008
UniProt ID (eCommerce)
Q9NPF5
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.