human DIAPH2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human DIAPH2.
shADV-206985
Ad-h-DIAPH2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human DIAPH2 (diaphanous related formin 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DIA; DIA2; diaphanous homolog 2; Diaphanous-related formin-2; diaphorase-2; DRF2; POF; POF2; POF2A; protein diaphanous homolog 2
Description (eCommerce)
Diaphanous 2 is a member of the formin family of proteins that is responsible for actin polymerization and nucleation activity and the formation of linear, unbranched actin cables and stress fibers. Diaphanous 1 is a target of the small GTPase, Rho. RhoB and diaphanous 2 have been shown to interact on endosomes and control actin dynamics involved in vesicle trafficking.
Description (Vector)
The product of this gene belongs to the diaphanous subfamily of the formin homology family of proteins. This gene may play a role in the development and normal function of the ovaries. Defects in this gene have been linked to premature ovarian failure 2. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
1730
Gene Name (eCommerce)
diaphanous related formin 2
Gene Name (Vector)
diaphanous related formin 2
Gene Symbol
DIAPH2
HGNC ID
HGNC:2877
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3312
ORF Size (bp)
3312 bp
Protein Name (eCommerce)
Protein diaphanous homolog 2
RefSeq ID
NM_006729
RefSeq Synonyms
NM_007309, NM_006729, BC143838, BC117414,
Research Areas
Cytoskeleton,Golgi Apparatus,Mitochondrion
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Diaphanous 2 is a member of the formin family of proteins that is responsible for actin polymerization and nucleation activity and the formation of linear, unbranched actin cables and stress fibers. Diaphanous 1 is a target of the small GTPase, Rho. RhoB and diaphanous 2 have been shown to interact on endosomes and control actin dynamics involved in vesicle trafficking.
UniGene ID
Hs.716101
UniProt ID (eCommerce)
O60879
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.