human DENND1A shRNA silencing Adenovirus

Name
Ad-h-DENND1A-shRNA

Cat No
shADV-206864

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human DENND1A.

shADV-206864

Ad-h-DENND1A-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DENND1A (DENN domain containing 1A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

FAM31A; KIAA1608

Description (Vector)

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 (PubMed 20154091)).(supplied by OMIM, Nov 2010)

Gene ID

57706

Gene Name (Vector)

DENN domain containing 1A

Gene Symbol

DENND1A

HGNC ID

HGNC:29324

ORF Size (aa)

1680

ORF Size (bp)

1680 bp

RefSeq ID

NM_024820

RefSeq Synonyms

NM_024820, NM_020946, BC039703,

Species

human

UniGene ID

Hs.568340

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.