human DDB2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human DDB2.
shADV-206696
Ad-h-DDB2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human DDB2 (damage specific DNA binding protein 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DDBB; UV-DDB2; XPE
Description (Vector)
DDB2 encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities.
Gene ID
1643
Gene Name (Vector)
damage specific DNA binding protein 2
Gene Symbol
DDB2
HGNC ID
HGNC:2718
ORF Size (aa)
1284
ORF Size (bp)
1284 bp
RefSeq ID
NM_000107
RefSeq Synonyms
NM_001300734, NM_000107, BC000093,
Species
human
UniGene ID
Hs.700338
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.