human DCTN3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human DCTN3.
shADV-206676
Ad-h-DCTN3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human DCTN3 (dynactin subunit 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DCTN-22; DCTN22
Description (Vector)
DCTN3 encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants.
Gene ID
11258
Gene Name (Vector)
dynactin subunit 3
Gene Symbol
DCTN3
HGNC ID
HGNC:2713
ORF Size (aa)
531
ORF Size (bp)
531 bp
RefSeq ID
NM_007234
RefSeq Synonyms
NM_024348, NM_007234, NM_001281427, NM_001281426, NM_001281425, BC107697, BC003004, BC000319,
Species
human
UniGene ID
Hs.511768
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.